Genetic variants in the MRPS30 region and postmenopausal breast cancer risk.

ABSTRACT:

Background

Genome-wide association studies have identified several genomic regions that are associated with breast cancer risk, but these provide an explanation for only a small fraction of familial breast cancer aggregation. Genotype by environment interactions may contribute further to such explanation, and may help to refine the genomic regions of interest.

Methods

We examined genotypes for 4,988 SNPs, selected from recent genome-wide studies, and four randomized hormonal and dietary interventions among 2,166 women who developed invasive breast cancer during the intervention phase of the Women's Health Initiative (WHI) clinical trial (1993 to 2005), and one-to-one matched controls. These SNPs derive from 3,224 genomic regions having pairwise squared correlation (r2) betwe

SUBMITTER: Huang Y 

PROVIDER: S-EPMC3218816 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature