Genomic structure of the gene for mouse germ-cell nuclear factor (GCNF). II. Comparison with the genomic structure of the human GCNF gene.

ABSTRACT:

Background

Germ-cell nuclear factor (GCNF, NR6AI) is an orphan nuclear receptor. Its expression pattern suggests it functions during embryogenesis, in the placenta and in germ-cell development. Mouse GCNF cDNA codes for a protein of 495 amino acids, whereas the four reported human cDNA variants code for proteins of 454 to 480 amino acids. Apart from this size difference, there is sequence conservation of up to 98.7%. To elucidate the genomic structure that gives rise to the different human GCNF mRNAs, the sequence information of the human GCNF locus is compared to the previously reported structure of the mouse locus.

Results

The genomic structures of the mouse and human GCNF genes are highly conserved. The comparison reveals that the shorter human protein results from skippi

SUBMITTER: Susens U 

PROVIDER: S-EPMC32189 | biostudies-literature | 2001

REPOSITORIES: biostudies-literature