Sedation and renal impairment in critically ill patients: a post hoc analysis of a randomized trial.

ABSTRACT:

Introduction

Not sedating critically ill patients reduces the time patients receive mechanical ventilation, decreases the time in the intensive care department and reduces the total hospital length of stay. We hypothesized that no sedation improves hemodynamic stability, decreases the need for vasoactive drugs, diminishes the need for extra fluids and lowers the risk of acute kidney injury.

Methods

We performed an evaluation on the database from our previous trial of 140 patients randomized to either no sedation vs. sedation with a daily interruption of sedatives. A total of 113 patients were included in the previous statistical analysis. Ten patients had pre-existing renal impairments and were excluded. Data were collected from observational cards and blood samples.

Resu

SUBMITTER: Strom T 

PROVIDER: S-EPMC3218972 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature