Association between IL-32 genotypes and outcome in infection-associated acute lung injury.

ABSTRACT:

Introduction

Our purpose was to investigate variation within the IL-32 promoter and gene, and susceptibility to and outcomes from infection associated acute lung injury (ALI).

Methods

Retrospective case-control study involving healthy individuals (controls) and patients (cases) with infection-associated ALI. Two hundred fifty-eight healthy normal controls and 251 patients with infection-associated ALI were used for comparison. The IL-32 promoter/gene was sequenced in 52 healthy Caucasian individuals to identify single nucleotide polymorphisms (SNPs). Allelic discrimination was performed on 11 SNPs to determine differences between cases and controls and outcomes in patients with infection associated ALI.

Results

Logistic and normal regression models were used to evalua

SUBMITTER: Arcaroli JJ 

PROVIDER: S-EPMC3219007 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature