Ontology highlight
ABSTRACT:
SUBMITTER: Chaiwatanasirikul KA
PROVIDER: S-EPMC3219095 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Chaiwatanasirikul K-A KA Sala A A
Cell death & disease 20111020
The product of the CLU gene promotes or inhibits tumourigenesis in a context-dependent manner. It has been hypothesised that different CLU isoforms have different and even opposing biological functions, but this theory has not been experimentally validated. Here we show that molecules involved in survival pathways are differentially modulated by the intracellular or secreted forms of CLU. Secreted CLU, which is selectively increased after transformation, activates the survival factor AKT, wherea ...[more]