Ontology highlight
ABSTRACT:
SUBMITTER: Hayashi H
PROVIDER: S-EPMC3219097 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Hayashi Hideki H Kohno Tomoko T Yasui Kiyoshi K Murota Hiroyuki H Kimura Tohru T Duncan Gordon S GS Nakashima Tomoki T Yamamoto Kazuo K Katayama Ichiro I Ma Yuhua Y Chua Koon Jiew KJ Suematsu Takashi T Shimokawa Isao I Akira Shizuo S Kubo Yoshinao Y Mak Tak Wah TW Matsuyama Toshifumi T
Proceedings of the National Academy of Sciences of the United States of America 20111031 46
Mice deficient for interferon regulatory factor (Irf)2 (Irf2(-/-) mice) exhibit immunological abnormalities and cannot survive lymphocytic choriomeningitis virus infection. The pancreas of these animals is highly inflamed, a phenotype replicated by treatment with poly(I:C), a synthetic double-stranded RNA. Trypsinogen5 mRNA was constitutively up-regulated about 1,000-fold in Irf2(-/-) mice compared with controls as assessed by quantitative RT-PCR. Further knockout of IFNα/β receptor 1(Ifnar1) ab ...[more]