Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression.

ABSTRACT:

Introduction

Pokemon is an oncogenic transcription factor involved in cell growth, differentiation and oncogenesis, but little is known about its role in human breast cancer. In this study, we aimed to reveal the role of Pokemon in breast cancer progression and patient survival and to understand its underlying mechanisms.

Methods

Tissue microarray analysis of breast cancer tissues from patients with complete clinicopathological data and more than 20 years of follow-up were used to evaluate Pokemon expression and its correlation with the progression and prognosis of the disease. DNA microarray analysis of MCF-7 cells that overexpress Pokemon was used to identify Pokemon target genes. Chromatin immunoprecipitation (ChIP) and site-directed mutagenesis were utilized to determine

SUBMITTER: Zu X 

PROVIDER: S-EPMC3219187 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature