A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology.

ABSTRACT:

Background

Genome-scale metabolic reconstructions provide a biologically meaningful mechanistic basis for the genotype-phenotype relationship. The global human metabolic network, termed Recon 1, has recently been reconstructed allowing the systems analysis of human metabolic physiology and pathology. Utilizing high-throughput data, Recon 1 has recently been tailored to different cells and tissues, including the liver, kidney, brain, and alveolar macrophage. These models have shown utility in the study of systems medicine. However, no integrated analysis between human tissues has been done.

Results

To describe tissue-specific functions, Recon 1 was tailored to describe metabolism in three human cells: adipocytes, hepatocytes, and myocytes. These cell-specific networks were ma

SUBMITTER: Bordbar A 

PROVIDER: S-EPMC3219569 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature