Computational prediction of host-parasite protein interactions between P. falciparum and H. sapiens.

ABSTRACT: To obtain candidates of interactions between proteins of the malaria parasite Plasmodium falciparum and the human host, homologous and conserved interactions were inferred from various sources of interaction data. Such candidate interactions were assessed by applying a machine learning approach and further filtered according to expression and molecular characteristics, enabling involved proteins to indeed interact. The analysis of predicted interactions indicated that parasite proteins predominantly target central proteins to take control of a human host cell. Furthermore, parasite proteins utilized their protein repertoire in a combinatorial manner, providing a broad connection to host cellular processes. In particular, several prominent pathways of signaling and regulation proteins were

SUBMITTER: Wuchty S 

PROVIDER: S-EPMC3219658 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature