Menstrual cycle-related fluctuations in breast density measured by using three-dimensional MR imaging.

ABSTRACT:

Purpose

To investigate the fluctuation of fibroglandular tissue volume (FV) and percentage of breast density (PD) during the menstrual cycle and compare with postmenopausal women by using three-dimensional magnetic resonance (MR)-based segmentation methods.

Materials and methods

This study was approved by the Institutional Review Board and was HIPAA compliant. Written informed consent was obtained. Thirty healthy female subjects, 24 premenopausal and six postmenopausal, were recruited. All subjects underwent MR imaging examination each week for 4 consecutive weeks. The breast volume (BV), FV, and PD were measured by two operators to evaluate interoperator variation. The fluctuation of each parameter measured over the course of the four examinations was evaluated on the basis

SUBMITTER: Chan S 

PROVIDER: S-EPMC3219914 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature