Dynamic reprogramming of chromatin accessibility during Drosophila embryo development.

ABSTRACT:

Background

The development of complex organisms is believed to involve progressive restrictions in cellular fate. Understanding the scope and features of chromatin dynamics during embryogenesis, and identifying regulatory elements important for directing developmental processes remain key goals of developmental biology.

Results

We used in vivo DNaseI sensitivity to map the locations of regulatory elements, and explore the changing chromatin landscape during the first 11 hours of Drosophila embryonic development. We identified thousands of conserved, developmentally dynamic, distal DNaseI hypersensitive sites associated with spatial and temporal expression patterning of linked genes and with large regions of chromatin plasticity. We observed a nearly uniform balance between d

SUBMITTER: Thomas S 

PROVIDER: S-EPMC3219966 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature