Genetic susceptibility to distinct bladder cancer subphenotypes.

ABSTRACT:

Background

Clinical, pathologic, and molecular evidence indicate that bladder cancer is heterogeneous with pathologic/molecular features that define distinct subphenotypes with different prognoses. It is conceivable that specific patterns of genetic susceptibility are associated with particular subphenotypes.

Objective

To examine evidence for the contribution of germline genetic variation to bladder cancer heterogeneity.

Design, setting, and participants

The Spanish Bladder Cancer/EPICURO Study is a case-control study based in 18 hospitals located in five areas in Spain. Cases were patients with a newly diagnosed, histologically confirmed, urothelial cell carcinoma of the bladder from 1998 to 2001. Case diagnoses were reviewed and uniformly classified by pathologists

SUBMITTER: Guey LT 

PROVIDER: S-EPMC3220186 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature