Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway.

ABSTRACT: Cancer progression involves multiple complex and interdependent steps, including progressive proliferation, angiogenesis and metastases. The complexity of these processes requires a comprehensive elucidation of the integrated signaling networks for better understanding. EAPII interacts with multiple cancer-related proteins, but its biological significance in cancer development remains unknown. In this report we identified the elevated level of EAPII protein in non-small-cell lung carcinoma (NSCLC) patients and NSCLC cell lines in culture. The oncogenic role of EAPII in lung cancer development was demonstrated using NSCLC cells with genetic manipulations that influence EAPII expression: EAPII overexpression increases proliferation of NSCLC cells with an accelerated transition of cell cycle

SUBMITTER: Li C 

PROVIDER: S-EPMC3220271 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature