Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria.

ABSTRACT: Maintaining cellular lipid homeostasis is crucial to oxidative tissues, and it becomes compromised in obesity. Lipid droplets (LD) play a central role in lipid homeostasis by mediating fatty acid (FA) storage in the form of triglyceride, thereby lowering intracellular levels of lipids that mediate cellular lipotoxicity. LDs and mitochondria have interconnected functions, and anecdotal evidence suggests they physically interact. However, the mechanisms of interaction have not been identified. Perilipins are LD-scaffolding proteins and potential candidates to play a role in their interaction with mitochondria. We examined the contribution of LD perilipin composition to the physical and metabolic interactions between LD and mitochondria using multiple techniques: confocal imaging, electron mi

SUBMITTER: Wang H 

PROVIDER: S-EPMC3220284 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature