P53 codon 72 polymorphism and recurrent pregnancy loss: a meta-analysis.

ABSTRACT:

Background

Arg72Pro polymorphism of the p53 tumour suppressor gene have been associated with recurrent pregnancy loss. However, results were inconsistent. We performed this metaanalysis to drive amore precise estimation of association between p53 codon 72 polymorphism and recurrent pregnancy loss.

Methods

Electronic searche of PubMed was conducted to select studies. Case-control studies containing available genotype frequencies of Arg72Pro were chose, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association.

Results

4 case-control studies including 523 cases and 378controls were identified. This meta-analysis showed that individuals with the homozygous Pro/Pro genotype had increased risk of recurrent pregnancy loss (OR

SUBMITTER: Tang W 

PROVIDER: S-EPMC3220438 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature