Structural analysis of hubs in human NR-RTK network.

ABSTRACT:

Background

Currently a huge amount of protein-protein interaction data is available therefore extracting meaningful ones are a challenging task. In a protein-protein interaction network, hubs are considered as key proteins maintaining function and stability of the network. Therefore, studying protein-protein complexes from a structural perspective provides valuable information for predicted interactions.

Results

In this study, we have predicted by comparative modelling and docking methods protein-protein complexes of hubs of human NR-RTK network inferred from our earlier study. We found that some interactions are mutually excluded while others could occur simultaneously. This study revealed by structural analysis the key role played by Estrogen receptor (ESR1) in mediating t

SUBMITTER: Choura M 

PROVIDER: S-EPMC3220635 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature