An experimentally-supported genome-scale metabolic network reconstruction for Yersinia pestis CO92.

ABSTRACT:

Background

Yersinia pestis is a gram-negative bacterium that causes plague, a disease linked historically to the Black Death in Europe during the Middle Ages and to several outbreaks during the modern era. Metabolism in Y. pestis displays remarkable flexibility and robustness, allowing the bacterium to proliferate in both warm-blooded mammalian hosts and cold-blooded insect vectors such as fleas.

Results

Here we report a genome-scale reconstruction and mathematical model of metabolism for Y. pestis CO92 and supporting experimental growth and metabolite measurements. The model contains 815 genes, 678 proteins, 963 unique metabolites and 1678 reactions, accurately simulates growth on a range of carbon sources both qualitatively and quantitatively, and identifies gaps in severa

SUBMITTER: Charusanti P 

PROVIDER: S-EPMC3220653 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature