Combining classical and molecular approaches elaborates on the complexity of mechanisms underpinning anterior regeneration.

ABSTRACT: The current model of planarian anterior regeneration evokes the establishment of low levels of Wnt signalling at anterior wounds, promoting anterior polarity and subsequent elaboration of anterior fate through the action of the TALE class homeodomain PREP. The classical observation that decapitations positioned anteriorly will regenerate heads more rapidly than posteriorly positioned decapitations was among the first to lead to the proposal of gradients along an anteroposterior (AP) axis in a developmental context. An explicit understanding of this phenomenon is not included in the current model of anterior regeneration. This raises the question what the underlying molecular and cellular basis of this temporal gradient is, whether it can be explained by current models and whether understan

SUBMITTER: Evans DJ 

PROVIDER: S-EPMC3220713 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature