Sustained versus transient brain responses in schizophrenia: the role of intrinsic neural activity.

ABSTRACT: Schizophrenia patients (SZ) show early visual processing deficits in many, but not all, tasks. These deficits may be associated with dysregulation of intrinsic oscillatory activity that compromises signal-to-noise in the SZ brain. This question was studied using visual steady-state stimulation and post-steady-state presentation of transient visual stimuli. SZ had higher intrinsic oscillatory activity at the steady-state stimulation frequency (12.5 Hz) and at the 6.25 Hz subharmonic, showed a significant decrease in visual steady-state magnitude over 2s of stimulation, and were unable to promptly terminate the steady-state response following stimulation offset. If adjustment for levels of intrinsic brain activity were made, however, it would have appeared that SZ had activity of similar mag

SUBMITTER: Ethridge L 

PROVIDER: S-EPMC3220784 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature