Diabetes and risk of Parkinson's disease: a systematic review and meta-analysis.

ABSTRACT:

Objective

Diabetes has been associated with chronic neurodegeneration. We performed a systematic review and meta-analysis to assess the relationship between pre-existing diabetes and Parkinson's disease (PD).

Research design and methods

Original articles in English published up to 10 May 2011 were searched for in electronic databases (PubMed, Embase, and Scopus) and by reviewing references of eligible articles. Prospective cohort and case-control studies providing risk and precision estimates relating to pre-existing diabetes and PD were considered eligible.

Results

Nine studies/1,947 citations (cohort, N = 4; case-control, N = 5) fulfilled inclusion criteria for meta-analysis. In prospective studies, the onset of diabetes before onset of PD was found to be a risk fac

SUBMITTER: Cereda E 

PROVIDER: S-EPMC3220864 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature