Evaluation of nonfasting tests to screen for childhood and adolescent dysglycemia.

ABSTRACT:

Objective

To assess performance of nonfasting tests to screen children for dysglycemia (prediabetes or diabetes).

Research design and methods

This was a cross-sectional study of 254 overweight or obese (BMI ≥85th percentile) children aged 10-17 years. Subjects came for two visits to a clinical research unit. For visit one, they arrived fasting and a 2-h glucose tolerance test and HbA(1c) and fructosamine testing were performed. For visit two, they arrived nonfasting and had a random plasma glucose, a 1-h 50-g nonfasting glucose challenge test (1-h GCT), and urine dipstick performed. The primary end point was dysglycemia (fasting plasma glucose ≥100 mg/dL or a 2-h postglucose ≥140 mg/dL). Test performance was assessed using receiver operating characteristic (ROC) curves and c

SUBMITTER: Lee JM 

PROVIDER: S-EPMC3220868 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature