Histological and ultrastructural comparison of cauterization and thrombosis stroke models in immune-deficient mice.

ABSTRACT:

Background

Stroke models are essential tools in experimental stroke. Although several models of stroke have been developed in a variety of animals, with the development of transgenic mice there is the need to develop a reliable and reproducible stroke model in mice, which mimics as close as possible human stroke.

Methods

BALB/Ca-RAG2-/-γc-/- mice were subjected to cauterization or thrombosis stroke model and sacrificed at different time points (48hr, 1wk, 2wk and 4wk) after stroke. Mice received BrdU to estimate activation of cell proliferation in the SVZ. Brains were processed for immunohistochemical and EM.

Results

In both stroke models, after inflammation the same glial scar formation process and damage evolution takes place. After stroke, necrotic tissue is progre

SUBMITTER: Mora-Lee S 

PROVIDER: S-EPMC3221623 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature