The new platinum-based anticancer agent LA-12 induces retinol binding protein 4 in vivo.

ABSTRACT:

Background

The initial pharmacokinetic study of a new anticancer agent (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum (IV) (LA-12) was complemented by proteomic screening of rat plasma. The objective of the study was to identify new LA-12 target proteins that serve as markers of LA-12 treatment, response and therapy monitoring.

Methods

Proteomic profiles were measured by surface-enhanced laser desorption-ionization time-of-flight mass spectrometry (SELDI-TOF MS) in 72 samples of rat plasma randomized according to LA-12 dose and time from administration. Correlation of 92 peak clusters with platinum concentration was evaluated using Spearman correlation analysis.

Results

We identified Retinol-binding protein 4 (RBP4) whose level correlated with LA-12 le

SUBMITTER: Bouchal P 

PROVIDER: S-EPMC3221626 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature