SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster.

ABSTRACT:

Background

The SWI/SNF chromatin remodeling factors have the ability to remodel nucleosomes and play essential roles in key developmental processes. SWI/SNF complexes contain one subunit with ATPase activity, which in Drosophila melanogaster is called Brahma (Brm). The regulatory activities of SWI/SNF have been attributed to its influence on chromatin structure and transcription regulation, but recent observations have revealed that the levels of Brm affect the relative abundances of transcripts that are formed by alternative splicing and/or polyadenylation of the same pre-mRNA.

Results

We have investigated whether the function of Brm in pre-mRNA processing in Drosophila melanogaster is mediated by Brm alone or by the SWI/SNF complex. We have analyzed the effects of depletin

SUBMITTER: Waldholm J 

PROVIDER: S-EPMC3221629 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature