Targeting of mitochondria-endoplasmic reticulum by fluorescent macrocyclic compounds.

ABSTRACT:

Background

Useful probes of the intracellular environment that target a specific organelle in order to allow direct observation of the changes in these regions is of high current interest. Macrocyclic ligands have already revealed themselves as important selective hosts in some biological applications, forming stable and specific complexes. Therefore, in this paper, several macrocyclic ligands are evaluated as potential molecular probes.

Methodology

Four polyammonium macrocycles and one macrotricyclic bearing pyridine and phenanthroline chromophores have been synthesised and evaluated as molecular probes. The cytotoxicity of the compounds has been analyzed using human breast cancer cells (MCF-7), non-cancerous human dermal fibroblasts (NHDF) and human adult dermal skin fibro

SUBMITTER: Cruz C 

PROVIDER: S-EPMC3221659 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature