Insulin receptor-mediated signaling via phospholipase C-γ regulates growth and differentiation in Drosophila.

ABSTRACT: Coordination between growth and patterning/differentiation is critical if appropriate final organ structure and size is to be achieved. Understanding how these two processes are regulated is therefore a fundamental and as yet incompletely answered question. Here we show through genetic analysis that the phospholipase C-γ (PLC-γ) encoded by small wing (sl) acts as such a link between growth and patterning/differentiation by modulating some MAPK outputs once activated by the insulin pathway; particularly, sl promotes growth and suppresses ectopic differentiation in the developing eye and wing, allowing cells to attain a normal size and differentiate properly. sl mutants have previously been shown to have a combination of both growth and patterning/differentiation phenotypes: small wings, ect

SUBMITTER: Murillo-Maldonado JM 

PROVIDER: S-EPMC3221684 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature