Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer.

ABSTRACT:

Background & aims

Expression of the netrin-1 dependence receptor UNC5C is reduced in many colorectal tumors; mice with the UNC5C mutations have increased progression of intestinal tumors. We investigated whether specific variants in UNC5C increase risk of colorectal cancer (CRC).

Methods

We analyzed the sequence of UNC5C in blood samples from 1801 patients with CRC and 4152 controls from 3 cohorts (France, United States, and Finland). Almost all cases from France and the United States had familial CRC; of the Finnish cases, 92 of 984 were familial. We analyzed whether CRC segregates with the UNC5C variant A628K in 3 families with histories of CRC. We also performed haplotype analysis to determine the origin of this variant.

Results

Of 817 patients with familial CRC, 1

SUBMITTER: Coissieux MM 

PROVIDER: S-EPMC3221775 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature