Urease activity as a risk factor for caries development in children during a three-year study period: a survival analysis approach.

ABSTRACT:

Unlabelled

Recent cross-sectional studies suggest that reduced ability to generate alkali via the urease pathway in dental plaque may be an important caries risk factor, but it has not been assessed prospectively.

Objective

To evaluate the effect of plaque and saliva urease activity on the risk for developing new caries over a three-year period in children.

Methods

A panel of 80 children, three to six years of age at recruitment, was followed prospectively for three years. Plaque urease activity, saliva urease activity and dental caries were measured every six months. Survival analysis methodology was used to evaluate the effect of urease on caries development during the study period adjusted for gender, age, baseline caries levels, sugar consumption, amount of plaque

SUBMITTER: Morou-Bermudez E 

PROVIDER: S-EPMC3221879 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature