Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population.

ABSTRACT:

Introduction

Deregulated or excessive host immune responses contribute to the pathogenesis of sepsis. Toll-like receptor (TLR) signaling pathways and their negative regulators play a pivotal role in the modulation of host immune responses and the development of sepsis. The objective of this study was to investigate the association of variants in the TLR signaling pathway genes and their negative regulator genes with susceptibility to sepsis in the Chinese Han population.

Methods

Patients with severe sepsis (n = 378) and healthy control subjects (n = 390) were enrolled. Five genes, namely TLR2, TLR4, TLR9, MyD88 and TOLLIP, were investigated for their association with sepsis susceptibility by a tag single nucleotide polymorphism (SNP) strategy. Twelve tag SNPs were selected b

SUBMITTER: Song Z 

PROVIDER: S-EPMC3222042 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature