Eph/ephrin interactions modulate muscle satellite cell motility and patterning.

ABSTRACT: During development and regeneration, directed migration of cells, including neural crest cells, endothelial cells, axonal growth cones and many types of adult stem cells, to specific areas distant from their origin is necessary for their function. We have recently shown that adult skeletal muscle stem cells (satellite cells), once activated by isolation or injury, are a highly motile population with the potential to respond to multiple guidance cues, based on their expression of classical guidance receptors. We show here that, in vivo, differentiated and regenerating myofibers dynamically express a subset of ephrin guidance ligands, as well as Eph receptors. This expression has previously only been examined in the context of muscle-nerve interactions; however, we propose that it might also

SUBMITTER: Stark DA 

PROVIDER: S-EPMC3222207 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature