DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness.

ABSTRACT: Disrupted in schizophrenia 1 (DISC1) is well established as a genetic risk factor across a spectrum of psychiatric disorders, a role supported by a growing body of biological studies, making the DISC1 protein interaction network an attractive therapeutic target. By contrast, there is a relative deficit of structural information to relate to the myriad biological functions of DISC1. Here, we critically appraise the available bioinformatics and biochemical analyses on DISC1 and key interacting proteins, and integrate this with the genetic and biological data. We review, analyze, and make predictions regarding the secondary structure and propensity for disordered regions within DISC1, its protein-interaction domains, subcellular localization motifs, and the structural and functional implicati

SUBMITTER: Soares DC 

PROVIDER: S-EPMC3222219 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature