Long-term mortality in patients with tuberculous meningitis: a Danish nationwide cohort study.

ABSTRACT:

Background

With high short-term mortality and substantial excess morbidity among survivors, tuberculous meningitis (TBM) is the most severe manifestation of extra-pulmonary tuberculosis (TB). The objective of this study was to assess the long-term mortality and causes of death in a TBM patient population compared to the background population.

Methods

A nationwide cohort study was conducted enrolling patients notified with TBM in Denmark from 1972-2008 and alive one year after TBM diagnosis. Data was extracted from national registries. From the background population we identified a control cohort of individuals matched on gender and date of birth. Kaplan-Meier survival curves and Cox regression analysis were used to estimate mortality rate ratios (MRR) and analyse causes of d

SUBMITTER: Christensen AS 

PROVIDER: S-EPMC3222654 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature