Ontology highlight
ABSTRACT:
SUBMITTER: Takai KK
PROVIDER: S-EPMC3222871 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Takai Kaori K KK Kibe Tatsuya T Donigian Jill R JR Frescas David D de Lange Titia T
Molecular cell 20111101 4
To prevent ATR activation, telomeres deploy the single-stranded DNA binding activity of TPP1/POT1a. POT1a blocks the binding of RPA to telomeres, suggesting that ATR is repressed through RPA exclusion. However, comparison of the DNA binding affinities and abundance of TPP1/POT1a and RPA indicates that TPP1/POT1a by itself is unlikely to exclude RPA. We therefore analyzed the central shelterin protein TIN2, which links TPP1/POT1a (and POT1b) to TRF1 and TRF2 on the double-stranded telomeric DNA. ...[more]