Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collections.

ABSTRACT:

Background

Human exposure to bisphenol A (BPA) is widespread. After exposure, BPA is rapidly metabolized and eliminated in urine. Therefore, there is considerable within-person and between-person variability of BPA concentrations in spot urine samples. However, no information exists on the within-day variability of urinary BPA concentrations.

Objectives

We examined the between-person and within-person and between-day and within-day variability in the urinary BPA concentrations of eight adults who collected all voids for 1 week to investigate the impact of sampling strategy in the exposure assessment of BPA using spot, first morning, or 24-hr urine collections.

Methods

We determined the urinary concentrations of BPA using on-line solid-phase extraction coupled to isoto

SUBMITTER: Ye X 

PROVIDER: S-EPMC3223007 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature