Ambient air pollution and lipoprotein-associated phospholipase A₂ in survivors of myocardial infarction.

ABSTRACT:

Background

Increasing evidence suggests a proatherogenic role for lipoprotein-associated phospholipase A₂ (Lp-PLA2). A meta-analysis of published cohorts has shown that Lp-PLA2 is an independent predictor of coronary heart disease events and stroke.

Objective

In this study, we investigated whether the association between air pollution and cardiovascular disease might be partly explained by increased Lp-PLA2 mass in response to exposure.

Methods

A prospective longitudinal study of 200 patients who had had a myocardial infarction was performed in Augsburg, Germany. Up to six repeated clinical examinations were scheduled every 4-6 weeks between May 2003 and March 2004. Supplementary to the multicenter AIRGENE protocol, we assessed repeated plasma Lp-PLA2 concentrations.

SUBMITTER: Bruske I 

PROVIDER: S-EPMC3223011 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature