Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials.

ABSTRACT:

Objective

To assess the effect of targeting intensive glycaemic control versus conventional glycaemic control on all cause mortality and cardiovascular mortality, non-fatal myocardial infarction, microvascular complications, and severe hypoglycaemia in patients with type 2 diabetes.

Design

Systematic review with meta-analyses and trial sequential analyses of randomised trials.

Data sources

Cochrane Library, Medline, Embase, Science Citation Index Expanded, LILACS, and CINAHL to December 2010; hand search of reference lists and conference proceedings; contacts with authors, relevant pharmaceutical companies, and the US Food and Drug Administration.

Study selection

Randomised clinical trials comparing targeted intensive glycaemic control with conventional glycaem

SUBMITTER: Hemmingsen B 

PROVIDER: S-EPMC3223424 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature