Nanoparticle-mediated signaling endosome localization regulates growth cone motility and neurite growth.

ABSTRACT: Understanding neurite growth regulation remains a seminal problem in neurobiology. During development and regeneration, neurite growth is modulated by neurotrophin-activated signaling endosomes that transmit regulatory signals between soma and growth cones. After injury, delivering neurotrophic therapeutics to injured neurons is limited by our understanding of how signaling endosome localization in the growth cone affects neurite growth. Nanobiotechnology is providing new tools to answer previously inaccessible questions. Here, we show superparamagnetic nanoparticles (MNPs) functionalized with TrkB agonist antibodies are endocytosed into signaling endosomes by primary neurons that activate TrkB-dependent signaling, gene expression and promote neurite growth. These MNP signaling endosomes a

SUBMITTER: Steketee MB 

PROVIDER: S-EPMC3223462 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature