Genome-wide protein localization prediction strategies for gram negative bacteria.

ABSTRACT:

Background

Genome-wide prediction of protein subcellular localization is an important type of evidence used for inferring protein function. While a variety of computational tools have been developed for this purpose, errors in the gene models and use of protein sorting signals that are not recognized by the more commonly accepted tools can diminish the accuracy of their output.

Results

As part of an effort to manually curate the annotations of 19 strains of Shewanella, numerous insights were gained regarding the use of computational tools and proteomics data to predict protein localization. Identification of the suite of secretion systems present in each strain at the start of the process made it possible to tailor-fit the subsequent localization prediction strategies to eac

SUBMITTER: Romine MF 

PROVIDER: S-EPMC3223724 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature