Environment sensing and response mediated by ABC transporters.

ABSTRACT:

Background

Transporter proteins are one of an organism's primary interfaces with the environment. The expressed set of transporters mediates cellular metabolic capabilities and influences signal transduction pathways and regulatory networks. The functional annotation of most transporters is currently limited to general classification into families. The development of capabilities to map ligands with specific transporters would improve our knowledge of the function of these proteins, improve the annotation of related genomes, and facilitate predictions for their role in cellular responses to environmental changes.

Results

To improve the utility of the functional annotation for ABC transporters, we expressed and purified the set of solute binding proteins from Rhodopseudomonas

SUBMITTER: Giuliani SE 

PROVIDER: S-EPMC3223731 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature