Ontology highlight
ABSTRACT:
SUBMITTER: Pearson HB
PROVIDER: S-EPMC3223862 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Pearson Helen B HB Perez-Mancera Pedro A PA Dow Lukas E LE Ryan Andrew A Tennstedt Pierre P Bogani Debora D Elsum Imogen I Greenfield Andy A Tuveson David A DA Simon Ronald R Humbert Patrick O PO
The Journal of clinical investigation 20111003 11
Loss of cellular polarity is a hallmark of epithelial cancers, raising the possibility that regulators of polarity have a role in suppressing tumorigenesis. The Scribble complex is one of at least three interacting protein complexes that have a critical role in establishing and maintaining epithelial polarity. In human colorectal, breast, and endometrial cancers, expression of the Scribble complex member SCRIB is often mislocalized and deregulated. Here, we report that Scrib is indispensable for ...[more]