Modulation of the Chlamydia trachomatis in vitro transcriptome response by the sex hormones estradiol and progesterone.

ABSTRACT:

Background

Chlamydia trachomatis is a major cause of sexually transmitted disease in humans. Previous studies in both humans and animal models of chlamydial genital tract infection have suggested that the hormonal status of the genital tract epithelium at the time of exposure can influence the outcome of the chlamydial infection. We performed a whole genome transcriptional profiling study of C. trachomatis infection in ECC-1 cells under progesterone or estradiol treatment.

Results

Both hormone treatments caused a significant shift in the sub-set of genes expressed (25% of the transcriptome altered by more than 2-fold). Overall, estradiol treatment resulted in the down-regulation of 151 genes, including those associated with lipid and nucleotide metabolism. Of particular inte

SUBMITTER: Amirshahi A 

PROVIDER: S-EPMC3224131 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature