EnzymeDetector: an integrated enzyme function prediction tool and database.

ABSTRACT:

Background

The ability to accurately predict enzymatic functions is an essential prerequisite for the interpretation of cellular functions, and the reconstruction and analysis of metabolic models. Several biological databases exist that provide such information. However, in many cases these databases provide partly different and inconsistent genome annotations.

Description

We analysed nine prokaryotic genomes and found about 70% inconsistencies in the enzyme predictions of the main annotation resources. Therefore, we implemented the annotation pipeline EnzymeDetector. This tool automatically compares and evaluates the assigned enzyme functions from the main annotation databases and supplements them with its own function prediction. This is based on a sequence similarity anal

SUBMITTER: Quester S 

PROVIDER: S-EPMC3224133 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature