Role of the SaeRS two-component regulatory system in Staphylococcus epidermidis autolysis and biofilm formation.

ABSTRACT:

Background

Staphylococcus epidermidis (SE) has emerged as one of the most important causes of nosocomial infections. The SaeRS two-component signal transduction system (TCS) influences virulence and biofilm formation in Staphylococcus aureus. The deletion of saeR in S. epidermidis results in impaired anaerobic growth and decreased nitrate utilization. However, the regulatory function of SaeRS on biofilm formation and autolysis in S. epidermidis remains unclear.

Results

The saeRS genes of SE1457 were deleted by homologous recombination. The saeRS deletion mutant, SE1457ΔsaeRS, exhibited increased biofilm formation that was disturbed more severely (a 4-fold reduction) by DNase I treatment compared to SE1457 and the complementation strain SE1457saec. Compared to SE1457 and SE14

SUBMITTER: Lou Q 

PROVIDER: S-EPMC3224141 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature