Acute testosterone deprivation reduces insulin sensitivity in men.

ABSTRACT:

Objective

In men with prostate cancer, androgen deprivation reduces insulin sensitivity; however, the relative roles played by testosterone and estradiol are unknown. To investigate the respective effects of these hormones on insulin sensitivity in men, we employed a model of experimental hypogonadism with or without hormone replacement.

Design

Placebo-controlled, randomized trial.

Participants

Twenty-two healthy male volunteers, 18-55 years old.

Methods

Following screening, subjects received the gonadotrophin-releasing hormone antagonist acyline plus one of the following for 28 days: Group 1, placebo transdermal gel and placebo pills; Group 2, transdermal testosterone gel 10 g/day plus placebo pills; Group 3, transdermal testosterone gel 10 g/day plus the arom

SUBMITTER: Rubinow KB 

PROVIDER: S-EPMC3224202 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature