Prioritizing cancer-related genes with aberrant methylation based on a weighted protein-protein interaction network.

ABSTRACT:

Background

As an important epigenetic modification, DNA methylation plays a crucial role in the development of mammals and in the occurrence of complex diseases. Genes that interact directly or indirectly may have the same or similar functions in the biological processes in which they are involved and together contribute to the related disease phenotypes. The complicated relations between genes can be clearly represented using network theory. A protein-protein interaction (PPI) network offers a platform from which to systematically identify disease-related genes from the relations between genes with similar functions.

Results

We constructed a weighted human PPI network (WHPN) using DNA methylation correlations based on human protein-protein interactions. WHPN represents the

SUBMITTER: Liu H 

PROVIDER: S-EPMC3224234 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature