Pilot proof of concept clinical trials of Stochastic Targeted (STAR) glycemic control.

ABSTRACT:

Introduction

Tight glycemic control (TGC) has shown benefits but has been difficult to achieve consistently. STAR (Stochastic TARgeted) is a flexible, model-based TGC approach directly accounting for intra- and inter- patient variability with a stochastically derived maximum 5% risk of blood glucose (BG) < 4.0 mmol/L. This research assesses the safety, efficacy, and clinical burden of a STAR TGC controller modulating both insulin and nutrition inputs in pilot trials.

Methods

Seven patients covering 660 hours. Insulin and nutrition interventions are given 1-3 hourly as chosen by the nurse to allow them to manage workload. Interventions are calculated by using clinically validated computer models of human metabolism and its variability in critical illness to maximize the overl

SUBMITTER: Evans A 

PROVIDER: S-EPMC3224394 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature