Physiological modeling, tight glycemic control, and the ICU clinician: what are models and how can they affect practice?

ABSTRACT: Critically ill patients are highly variable in their response to care and treatment. This variability and the search for improved outcomes have led to a significant increase in the use of protocolized care to reduce variability in care. However, protocolized care does not address the variability of outcome due to inter- and intra-patient variability, both in physiological state, and the response to disease and treatment. This lack of patient-specificity defines the opportunity for patient-specific approaches to diagnosis, care, and patient management, which are complementary to, and fit within, protocolized approaches.Computational models of human physiology offer the potential, with clinical data, to create patient-specific models that capture a patient's physiological status. Such models

SUBMITTER: Chase JG 

PROVIDER: S-EPMC3224460 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature