Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?

ABSTRACT: Mitochondrial functions include production of energy, activation of programmed cell death, and a number of cell specific tasks, e.g., cell signaling, control of Ca2+ metabolism, and synthesis of a number of important biomolecules. As proper mitochondrial function is critical for normal performance and survival of cells, mitochondrial dysfunction often leads to pathological conditions resulting in various human diseases. Recently mitochondrial dysfunction has been linked to multiple organ failure (MOF) often leading to the death of critical care patients. However, there are two main reasons why this insight did not generate an adequate resonance in clinical settings. First, most data regarding mitochondrial dysfunction in organs susceptible to failure in critical care diseases (liver, kidne

SUBMITTER: Kozlov AV 

PROVIDER: S-EPMC3224479 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature