Dataset Information
Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk.
Ontology highlight
ABSTRACT: Background
Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in AD brain is the result of upregulation of tau kinases and downregulation of tau phosphatases.Methods
In a group of 729 Spanish late-onset Alzheimer's disease (AD) patients and 670 healthy controls, we examined variations into a set of candidate genes (PPP2CA, PPP2R2A, ANP32A, LCMT1, PPME1 and PIN1) in the tau protein phosphatase-2A (PP2A) pathway, to address hypotheses of genetic variation that might influence AD risk.Results
There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by age, gender or APOE ε4 allele.Conclusion
Our negative findings in the Spanish population argue against the hypothesis that genetic variation in the tau protein phosphatase-2A (PP2A) pathway is causally related to AD risk.
SUBMITTER: Vazquez-Higuera JL
PROVIDER: S-EPMC3224542 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk.
BMC research notes 20110907
<h4>Background</h4>Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in AD brain is the result of upregulation of tau kinases and downregulation of tau phosphatases.<h4>Methods</h4>In a group of 729 Spanish late-onset Alzheimer's disease (AD) patients and 670 healthy controls, we examined variations into a set of candidate genes (PPP2CA, PPP2R2A, ANP32A, LCMT1, PPME1 and PIN1) in the tau protein phosphatase-2A (PP2A) pathway, to address hypotheses of genetic variatio ...[more]