Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6.

ABSTRACT:

Background

Peroxisomes execute diverse and vital functions in virtually every eukaryote. New peroxisomes form by budding from pre-existing organelles or de novo by vesiculation of the ER. It has been suggested that ADP-ribosylation factors and COPI coatomer complexes are involved in these processes.

Results

Here we show that all viable Saccharomyces cerevisiae strains deficient in one of the small GTPases which have an important role in the regulation of vesicular transport contain functional peroxisomes, and that the number of these organelles in oleate-grown cells is significantly upregulated in the arf1 and arf3 null strains compared to the wild-type strain. In addition, we provide evidence that a portion of endogenous Arf6, the mammalian orthologue of yeast Arf3, is asso

SUBMITTER: Anthonio EA 

PROVIDER: S-EPMC3224584 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature